//location exosol : size = 0.00000000000991, type = compartment; //location cellMembrane in exosol : size = 0.000000126, type = membrane; //location cytosol in cellMembrane : size = 0.00000000000209, type = compartment; //location nucleus in cytosol : size = 0.00000000000025, type = compartment; //exosol = 0.00000000000991 * 100000; exosol = 0.00000000000991; cellMembrane = 0.000000126; cytosol = 0.00000000000209; nucleus = 0.00000000000025; LIF_init=3000; gp130_init=1000; LIFR_init=1000; OSM_init=3000; OSMR_init=1000; gp130:LIF:LIFR_init = 0; gp130:OSM:LIFR_init = 0; gp130:OSM:OSMR_init = 0; gp130_P:LIF:LIFR_init = 0; gp130:LIF:LIFR_P_init = 0; gp130_P:LIF:LIFR_P_init = 0; gp130_P:OSM:LIFR_init = 0; gp130:OSM:LIFR_P_init = 0; gp130_P:OSM:LIFR_P_init = 0; gp130_P:OSM:OSMR_init = 0; gp130:OSM:OSMR_P_init = 0; gp130_P:OSM:OSMR_P_init = 0; STAT3:gp130_P:LIF:LIFR_init = 0; gp130:LIF:LIFR_P:STAT3_init = 0; STAT3:gp130_P:LIF:LIFR_P_init = 0; gp130_P:LIF:LIFR_P:STAT3_init = 0; STAT3:gp130_P:LIF:LIFR_P:STAT3_init = 0; STAT3:gp130_P:OSM:LIFR_init = 0; gp130:OSM:LIFR_P:STAT3_init = 0; STAT3:gp130_P:OSM:LIFR_P_init = 0; gp130_P:OSM:LIFR_P:STAT3_init = 0; STAT3:gp130_P:OSM:LIFR_P:STAT3_init = 0; STAT3:gp130_P:OSM:OSMR_init = 0; gp130:OSM:OSMR_P:STAT3_init = 0; STAT3:gp130_P:OSM:OSMR_P_init = 0; gp130_P:OSM:OSMR_P:STAT3_init = 0; STAT3:gp130_P:OSM:OSMR_P:STAT3_init = 0; STAT3_P:gp130_P:LIF:LIFR_P:STAT3_init = 0; STAT3:gp130_P:LIF:LIFR_P:STAT3_P_init = 0; STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P_init = 0; STAT3_P:gp130_P:OSM:LIFR_P:STAT3_init = 0; STAT3:gp130_P:OSM:LIFR_P:STAT3_P_init = 0; STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P_init = 0; STAT3_P:gp130_P:OSM:OSMR_P:STAT3_init = 0; STAT3:gp130_P:OSM:OSMR_P:STAT3_P_init = 0; STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P_init = 0; STAT3_c_init = 3000; STAT3_PD_c_init = 0; STAT3_PD_n_init = 0; STAT3_n_init = 0; SOCS3_init = 0; SOCS3_dummy_source_init = 100000; SOCS3:gp130_P:LIF:LIFR_init = 0; gp130:LIF:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:LIF:LIFR_P_init = 0; gp130_P:LIF:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:LIF:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:LIFR_init = 0; gp130:OSM:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:LIFR_P_init = 0; gp130_P:OSM:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:LIFR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:OSMR_init = 0; gp130:OSM:OSMR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:OSMR_P_init = 0; gp130_P:OSM:OSMR_P:SOCS3_init = 0; SOCS3:gp130_P:OSM:OSMR_P:SOCS3_init = 0; PIAS3_init = 1000; PIAS3:STAT3_PD_n_init = 0; k1 = 4800000; km1 = 0.01; k2 = 4800000; km2 = 0.01; k3 = 4800000; km3 = 0.01; k4 = 4800000; km4 = 0.01; k5 = 4800000; km5 = 0.01; k6 = 4800000; km6 = 0.01; k7 = 0.2; km7 = 0.01; k8 = 0.2; km8 = 0.01; k9 = 0.2; km9 = 0.01; k10 = 0.2; km10 = 0.01; k11 = 0.2; km11 = 0.01; k12 = 0.2; km12 = 0.01; k13 = 0.2; km13 = 0.01; k14 = 0.2; km14 = 0.01; k15 = 0.2; km15 = 0.01; k16 = 0.2; km16 = 0.01; k17 = 0.2; km17 = 0.01; k18 = 0.2; km18 = 0.01; k19 = 0.2; km19 = 0.01; k20 = 0.2; km20 = 0.01; k21 = 0.2; km21 = 0.01; k22 = 0.2; km22 = 0.01; k23 = 0.2; km23 = 0.01; k24 = 0.2; km24 = 0.01; k25 = 480000000; km25 = 0.06; k26 = 480000000; km26 = 0.06; k27 = 480000000; km27 = 0.06; k28 = 480000000; km28 = 0.06; k29 = 480000000; km29 = 0.06; k30 = 480000000; km30 = 0.06; k31 = 480000000; km31 = 0.06; k32 = 480000000; km32 = 0.06; k33 = 480000000; km33 = 0.06; k34 = 480000000; km34 = 0.06; k35 = 480000000; km35 = 0.06; k36 = 480000000; km36 = 0.06; k37 = 480000000; km37 = 0.06; k38 = 480000000; km38 = 0.06; k39 = 480000000; km39 = 0.06; k40 = 480000000; km40 = 0.06; k41 = 480000000; km41 = 0.06; k42 = 480000000; km42 = 0.06; k43 = 0.2; km43 = 0.01; k44 = 0.2; km44 = 0.01; k45 = 0.2; km45 = 0.01; k46 = 0.2; km46 = 0.01; k47 = 0.2; km47 = 0.01; k48 = 0.2; km48 = 0.01; k49 = 0.2; km49 = 0.01; k50 = 0.2; km50 = 0.01; k51 = 0.2; km51 = 0.01; k52 = 0.2; km52 = 0.01; k53 = 0.2; km53 = 0.01; k54 = 0.2; km54 = 0.01; k55 = 1E+308; k56 = 1E+308; k57 = 1E+308; k58 = 1; k59 = 0.02; k60 = 15; k61 = 0.05; k62 = 60000000; km62 = 0.006; k63 = 60000000; km63 = 0.006; k64 = 60000000; km64 = 0.006; k65 = 60000000; km65 = 0.006; k66 = 60000000; km66 = 0.006; k67 = 60000000; km67 = 0.006; k68 = 60000000; km68 = 0.006; k69 = 60000000; km69 = 0.006; k70 = 60000000; km70 = 0.006; k71 = 60000000; km71 = 0.006; k72 = 60000000; km72 = 0.006; k73 = 60000000; km73 = 0.006; k74 = 60000000; km74 = 0.006; k75 = 60000000; km75 = 0.006; k76 = 60000000; km76 = 0.006; k77 = 60000000; km77 = 0.006; k78 = 60000000; km78 = 0.006; k79 = 60000000; km79 = 0.006; k80 = 100000000; km80 = 0.4; k81 = 0.01; na = 6.02E+023; //ligands_receptors binding/unbinding bind_gl_l_1 = [k1 / (exosol * na) * gp130 * LIF * LIFR ]; unbind_gl_l_1 = [km1 * gp130:LIF:LIFR ]; bind_ll_g_2 = [k2 / (exosol * na) * LIFR * LIF * gp130 ]; unbind_ll_g_2 = [km2 * gp130:LIF:LIFR ]; bind_go_l_3 = [k3 / (exosol * na) * gp130 * OSM * LIFR ]; unbind_go_l_3 = [km3 * gp130:OSM:LIFR ]; bind_lo_g_4 = [k4 / (exosol * na) * LIFR * OSM * gp130 ]; unbind_lo_g_4 = [km4 * gp130:OSM:LIFR ]; bind_oo_g_5 = [k5 / (exosol * na) * OSMR * OSM * gp130 ]; unbind_oo_g_5 = [km5 * gp130:OSM:OSMR ]; bind_go_o_6 = [k6 / (exosol * na) * gp130 * OSM * OSMR ]; unbind_go_o_6 = [km6 * gp130:OSM:OSMR ]; //receptors phosphorylation phospho_gll_7 = [k7 * gp130:LIF:LIFR ]; dephospho_gll_7 = [km7 * gp130_P:LIF:LIFR ]; phospho_gll_8 = [k8 * gp130:LIF:LIFR ]; dephospho_gll_8 = [km8 * gp130:LIF:LIFR_P ]; phospho_gll_9 = [k9 * gp130_P:LIF:LIFR ]; dephospho_gll_9 = [km9 * gp130_P:LIF:LIFR_P ]; phospho_gll_10 = [k10 * gp130:LIF:LIFR_P ]; dephospho_gll_10 = [km10 * gp130_P:LIF:LIFR_P ]; phospho_gol_11 = [k11 * gp130:OSM:LIFR ]; dephospho_gol_11 = [km11 * gp130_P:OSM:LIFR ]; phospho_gol_12 = [k12 * gp130:OSM:LIFR ]; dephospho_gol_12 = [km12 * gp130:OSM:LIFR_P ]; phospho_gol_13 = [k13 * gp130_P:OSM:LIFR ]; dephospho_gol_13 = [km13 * gp130_P:OSM:LIFR_P ]; phospho_gol_14 = [k14 * gp130:OSM:LIFR_P ]; dephospho_gol_14 = [km14 * gp130_P:OSM:LIFR_P ]; phospho_goo_15 = [k15 * gp130:OSM:OSMR ]; dephospho_goo_15 = [km15 * gp130_P:OSM:OSMR ]; phospho_goo_16 = [k16 * gp130:OSM:OSMR ]; dephospho_goo_16 = [km16 * gp130:OSM:OSMR_P ]; phospho_goo_17 = [k17 * gp130_P:OSM:OSMR ]; dephospho_goo_17 = [km17 * gp130_P:OSM:OSMR_P ]; phospho_goo_18 = [k18 * gp130:OSM:OSMR_P ]; dephospho_goo_18 = [km18 * gp130_P:OSM:OSMR_P ]; phospho_sgll_19 = [k19 * STAT3:gp130_P:LIF:LIFR ]; dephospho_sgll_19 = [km19 * STAT3:gp130_P:LIF:LIFR_P ]; phospho_glls_20 = [k20 * gp130:LIF:LIFR_P:STAT3 ]; dephospho_glls_20 = [km20 * gp130_P:LIF:LIFR_P:STAT3 ]; phospho_sgol_21 = [k21 * STAT3:gp130_P:OSM:LIFR ]; dephospho_sgol_21 = [km21 * STAT3:gp130_P:OSM:LIFR_P ]; phospho_gols_22 = [k22 * gp130:OSM:LIFR_P:STAT3 ]; dephospho_gols_22 = [km22 * gp130_P:OSM:LIFR_P:STAT3 ]; phospho_sgoo_23 = [k23 * STAT3:gp130_P:OSM:OSMR ]; dephospho_sgoo_23 = [km23 * STAT3:gp130_P:OSM:OSMR_P ]; phospho_goos_24 = [k24 * gp130:OSM:OSMR_P:STAT3 ]; dephospho_sgoo_24 = [km24 * STAT3:gp130_P:OSM:OSMR_P ]; //receptors_STAT3 binding/unbinding bind_gPll_stat_25 = [k25 / (cytosol * na) * gp130_P:LIF:LIFR * STAT3_c ]; unbind_gPll_stat_25 = [km25 * STAT3:gp130_P:LIF:LIFR ]; bind_gllP_stat_26 = [k26 / (cytosol * na) * gp130:LIF:LIFR_P * STAT3_c ]; unbind_gllP_stat_26 = [km26 * gp130:LIF:LIFR_P:STAT3 ]; bind_gPllP_stat_27 = [k27 / (cytosol * na) * gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_gPllP_stat_27 = [km27 * STAT3:gp130_P:LIF:LIFR_P ]; bind_gPllP_stat_28 = [k28 / (cytosol * na) * gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_gPllP_stat_28 = [km28 * gp130_P:LIF:LIFR_P:STAT3 ]; bind_sgPllP_stat_29 = [k29 / (cytosol * na) * STAT3:gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_sgPllP_stat_29 = [km29 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; bind_gPllPs_stat_30 = [k30 / (cytosol * na) * gp130_P:LIF:LIFR_P:STAT3 * STAT3_c ]; unbind_gPllPs_stat_30 = [km30 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; bind_gPol_stat_31 = [k31 / (cytosol * na) * gp130_P:OSM:LIFR * STAT3_c ]; unbind_gPol_stat_31 = [km31 * STAT3:gp130_P:OSM:LIFR ]; bind_golP_stat_32 = [k32 / (cytosol * na) * gp130:OSM:LIFR_P * STAT3_c ]; unbind_golP_stat_32 = [km32 * gp130:OSM:LIFR_P:STAT3 ]; bind_gPolP_stat_33 = [k33 / (cytosol * na) * gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_gPolP_stat_33 = [km33 * STAT3:gp130_P:OSM:LIFR_P ]; bind_gPolP_stat_34 = [k34 / (cytosol * na) * gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_gPolP_stat_34 = [km34 * gp130_P:OSM:LIFR_P:STAT3 ]; bind_sgPolP_stat_35 = [k35 / (cytosol * na) * STAT3:gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_sgPolP_stat_35 = [km35 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; bind_gPolPs_stat_36 = [k36 / (cytosol * na) * gp130_P:OSM:LIFR_P:STAT3 * STAT3_c ]; unbind_gPolPs_stat_36 = [km36 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; bind_gPoo_stat_37 = [k37 / (cytosol * na) * gp130_P:OSM:OSMR * STAT3_c ]; unbind_gPoo_stat_37 = [km37 * STAT3:gp130_P:OSM:OSMR ]; bind_gooP_stat_38 = [k38 / (cytosol * na) * gp130:OSM:OSMR_P * STAT3_c ]; unbind_gooP_stat_38 = [km38 * gp130:OSM:OSMR_P:STAT3 ]; bind_gPooP_stat_39 = [k39 / (cytosol * na) * gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_gPooP_stat_39 = [km39 * STAT3:gp130_P:OSM:OSMR_P ]; bind_gPooP_stat_40 = [k40 / (cytosol * na) * gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_gPooP_stat_40 = [km40 * gp130_P:OSM:OSMR_P:STAT3 ]; bind_sgPooP_stat_41 = [k41 / (cytosol * na) * STAT3:gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_sgPooP_stat_41 = [km41 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; bind_gPooPs_stat_42 = [k42 / (cytosol * na) * gp130_P:OSM:OSMR_P:STAT3 * STAT3_c ]; unbind_gPooPs_stat_42 = [km42 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; //STAT3 phosphorylation phospho_stat_sglls_43 = [k43 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; dephospho_stat_sglls_43 = [km43 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3 ]; phospho_stat_sglls_44 = [k44 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; dephospho_stat_sglls_44 = [km44 * STAT3:gp130_P:LIF:LIFR_P:STAT3_P ]; phospho_stat_sPglls_45 = [k45 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3 ]; dephospho_stat_sPglls_45 = [km45 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P ]; phospho_stat_sgllsP_46 = [k46 * STAT3:gp130_P:LIF:LIFR_P:STAT3_P ]; dephospho_stat_sgllsP_46 = [km46 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P ]; phospho_stat_sgols_47 = [k47 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; dephospho_stat_sgols_47 = [km47 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3 ]; phospho_stat_sgols_48 = [k48 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; dephospho_stat_sgols_48 = [km48 * STAT3:gp130_P:OSM:LIFR_P:STAT3_P ]; phospho_stat_sPgols_49 = [k49 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3 ]; dephospho_stat_sPgols_49 = [km49 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P ]; phospho_stat_sgolsP_50 = [k50 * STAT3:gp130_P:OSM:LIFR_P:STAT3_P ]; dephospho_stat_sgolsP_50 = [km50 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P ]; phospho_stat_sgoos_51 = [k51 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; dephospho_stat_sgoos_51 = [km51 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3 ]; phospho_stat_sgoos_52 = [k52 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; dephospho_stat_sgoos_52 = [km52 * STAT3:gp130_P:OSM:OSMR_P:STAT3_P ]; phospho_stat_sPgoos_53 = [k53 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3 ]; dephospho_stat_sPgoos_53 = [km53 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P ]; phospho_stat_sgoosP_54 = [k54 * STAT3:gp130_P:OSM:OSMR_P:STAT3_P ]; dephospho_stat_sgoosP_54 = [km54 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P ]; //STAT3 unbinding & homodimerization unbind_s_gll_55 = [k55 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P ]; unbind_s_gol_56 = [k56 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P ]; unbind_s_goo_57 = [k57 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P ]; //STAT3PD relocation cytoplasm -> nucleus reloc_stat_cn_58 = [(0.693 / k58) * STAT3_PD_c ]; //STAT3PDN dephosphorylation & dedimerization dephospho_dedimer_stat_59 = [k59 * STAT3_PD_n ]; //STAT3PDN relocation nucleus -> cytoplasm reloc_stat_nc_60 = [(0.693 / k60) * STAT3_n ]; //SOCS3 synthesis by STAT3_PD_n synth_socs_61 = [k61 * STAT3_PD_n ]; //receptors_SOCS3 binding/unbinding bind_gPll_socs_62 = [k62 / (cytosol * na) * gp130_P:LIF:LIFR * SOCS3 ]; unbind_gPll_socs_62 = [km62 * SOCS3:gp130_P:LIF:LIFR ]; bind_gllP_socs_63 = [k63 / (cytosol * na) * gp130:LIF:LIFR_P * SOCS3 ]; unbind_gllP_socs_63 = [km63 * gp130:LIF:LIFR_P:SOCS3 ]; bind_gPllP_socs_64 = [k64 / (cytosol * na) * gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_gPllP_socs_64 = [km64 * SOCS3:gp130_P:LIF:LIFR_P ]; bind_gPllP_socs_65 = [k65 / (cytosol * na) * gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_gPllP_socs_65 = [km65 * gp130_P:LIF:LIFR_P:SOCS3 ]; bind_sgPllP_socs_66 = [k66 / (cytosol * na) * SOCS3:gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_sgPllP_socs_66 = [km66 * SOCS3:gp130_P:LIF:LIFR_P:SOCS3 ]; bind_gPllPs_socs_67 = [k67 / (cytosol * na) * gp130_P:LIF:LIFR_P:SOCS3 * SOCS3 ]; unbind_gPllPs_socs_67 = [km67 * SOCS3:gp130_P:LIF:LIFR_P:SOCS3 ]; bind_gPol_socs_68 = [k68 / (cytosol * na) * gp130_P:OSM:LIFR * SOCS3 ]; unbind_gPol_socs_68 = [km68 * SOCS3:gp130_P:OSM:LIFR ]; bind_golP_socs_69 = [k69 / (cytosol * na) * gp130:OSM:LIFR_P * SOCS3 ]; unbind_golP_socs_69 = [km69 * gp130:OSM:LIFR_P:SOCS3 ]; bind_gPolP_socs_70 = [k70 / (cytosol * na) * gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_gPolP_socs_70 = [km70 * SOCS3:gp130_P:OSM:LIFR_P ]; bind_gPolP_socs_71 = [k71 / (cytosol * na) * gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_gPolP_socs_71 = [km71 * gp130_P:OSM:LIFR_P:SOCS3 ]; bind_sgPolP_socs_72 = [k72 / (cytosol * na) * SOCS3:gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_sgPolP_socs_72 = [km72 * SOCS3:gp130_P:OSM:LIFR_P:SOCS3 ]; bind_gPolPs_socs_73 = [k73 / (cytosol * na) * gp130_P:OSM:LIFR_P:SOCS3 * SOCS3 ]; unbind_gPolPs_socs_73 = [km73 * SOCS3:gp130_P:OSM:LIFR_P:SOCS3 ]; bind_gPoo_socs_74 = [k74 / (cytosol * na) * gp130_P:OSM:OSMR * SOCS3 ]; unbind_gPoo_socs_74 = [km74 * SOCS3:gp130_P:OSM:OSMR ]; bind_gooP_socs_75 = [k75 / (cytosol * na) * gp130:OSM:OSMR_P * SOCS3 ]; unbind_gooP_socs_75 = [km75 * gp130:OSM:OSMR_P:SOCS3 ]; bind_gPooP_socs_76 = [k76 / (cytosol * na) * gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_gPooP_socs_76 = [km76 * SOCS3:gp130_P:OSM:OSMR_P ]; bind_gPooP_socs_77 = [k77 / (cytosol * na) * gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_gPooP_socs_77 = [km77 * gp130_P:OSM:OSMR_P:SOCS3 ]; bind_sgPooP_socs_78 = [k78 / (cytosol * na) * SOCS3:gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_sgPooP_socs_78 = [km78 * SOCS3:gp130_P:OSM:OSMR_P:SOCS3 ]; bind_gPooPs_socs_79 = [k79 / (cytosol * na) * gp130_P:OSM:OSMR_P:SOCS3 * SOCS3 ]; unbind_gPooPs_socs_79 = [km79 * SOCS3:gp130_P:OSM:OSMR_P:SOCS3 ]; //PIAS3_STAT3PD_n bind_pias_stat_80 = [k80 / (nucleus * na) * PIAS3 * STAT3_PD_n ]; unbind_pias_stat_80 = [km80 * PIAS3:STAT3_PD_n ]; degr_socs_81 = [k81 * SOCS3 ]; //1 LIF = bind_gl_l_1 << + bind_ll_g_2 << + unbind_gl_l_1>> + unbind_ll_g_2>> ; //2 gp130 = bind_gl_l_1 << + bind_go_l_3 << + bind_go_o_6 << + bind_ll_g_2 << + bind_lo_g_4 << + bind_oo_g_5 << + unbind_gl_l_1>> + unbind_go_l_3>> + unbind_go_o_6>> + unbind_ll_g_2>> + unbind_lo_g_4>> + unbind_oo_g_5>> ; //3 LIFR = bind_ll_g_2 << + bind_lo_g_4 << + bind_gl_l_1 << + bind_go_l_3 << + unbind_ll_g_2>> + unbind_lo_g_4>> + unbind_gl_l_1>> + unbind_go_l_3>> ; //4 OSM = bind_go_l_3 << + bind_lo_g_4 << + bind_oo_g_5 << + bind_go_o_6 << + unbind_go_l_3>> + unbind_lo_g_4>> + unbind_oo_g_5>> + unbind_go_o_6>> ; //5 OSMR = bind_oo_g_5 << + bind_go_o_6 << + unbind_oo_g_5>> + unbind_go_o_6>> ; //6 gp130:LIF:LIFR = bind_gl_l_1 >> + bind_ll_g_2 >> + phospho_gll_7 << + phospho_gll_8 << + unbind_gl_l_1<< + unbind_ll_g_2<< + dephospho_gll_7>> + dephospho_gll_8>> ; //7 gp130:OSM:LIFR = bind_go_l_3 >> + bind_lo_g_4 >> + phospho_gol_11 << + phospho_gol_12 << + unbind_go_l_3<< + unbind_lo_g_4<< + dephospho_gol_11>> + dephospho_gol_12>> ; //8 gp130:OSM:OSMR = bind_oo_g_5 >> + bind_go_o_6 >> + phospho_goo_15 << + phospho_goo_16 << + unbind_oo_g_5<< + unbind_go_o_6<< + dephospho_goo_15>> + dephospho_goo_16>> ; //9 gp130_P:LIF:LIFR = phospho_gll_7 >> + phospho_gll_9 << + bind_gPll_stat_25<< + unbind_gPll_stat_25>> + bind_gPll_socs_62<< + unbind_gPll_socs_62>> + dephospho_gll_7<< + dephospho_gll_9>> ; //10 gp130:LIF:LIFR_P = phospho_gll_8 >> + phospho_gll_10 << + bind_gllP_stat_26<< + unbind_gllP_stat_26>> + bind_gllP_socs_63<< + unbind_gllP_socs_63>> + dephospho_gll_8<< + dephospho_gll_10>> ; //11 gp130_P:LIF:LIFR_P = phospho_gll_9 >> + phospho_gll_10 >> + bind_gPllP_stat_27<< + unbind_gPllP_stat_27>> + bind_gPllP_stat_28<< + unbind_gPllP_stat_28>> + unbind_s_gll_55>> + bind_gPllP_socs_64<< + unbind_gPllP_socs_64>> + bind_gPllP_socs_65<< + unbind_gPllP_socs_65>> + dephospho_gll_9<< + dephospho_gll_10<< ; //12 gp130_P:OSM:LIFR = phospho_gol_11 >> + phospho_gol_13 << + bind_gPol_stat_31<< + unbind_gPol_stat_31>> + bind_gPol_socs_68<< + unbind_gPol_socs_68>> + dephospho_gol_11<< + dephospho_gol_13>> ; //13 gp130:OSM:LIFR_P = phospho_gol_12 >> + phospho_gol_14 << + bind_golP_stat_32<< + unbind_golP_stat_32>> + bind_golP_socs_69<< + unbind_golP_socs_69>> + dephospho_gol_12<< + dephospho_gol_14>> ; //14 gp130_P:OSM:LIFR_P = phospho_gol_13 >> + phospho_gol_14 >> + bind_gPolP_stat_33<< + unbind_gPolP_stat_33>> + bind_gPolP_stat_34<< + unbind_gPolP_stat_34>> + unbind_s_gol_56>> + bind_gPolP_socs_70<< + unbind_gPolP_socs_70>> + bind_gPolP_socs_71<< + unbind_gPolP_socs_71>> + dephospho_gol_13<< + dephospho_gol_14<< ; //15 gp130_P:OSM:OSMR = phospho_goo_15 >> + phospho_goo_17 << + bind_gPoo_stat_37<< + unbind_gPoo_stat_37>> + bind_gPoo_socs_74<< + unbind_gPoo_socs_74>> + dephospho_goo_15<< + dephospho_goo_17>> ; //16 gp130:OSM:OSMR_P = phospho_goo_16 >> + phospho_goo_18 << + bind_gooP_stat_38<< + unbind_gooP_stat_38>> + bind_gooP_socs_75<< + unbind_gooP_socs_75>> + dephospho_goo_16<< + dephospho_goo_18>> ; //17 gp130_P:OSM:OSMR_P = phospho_goo_17 >> + phospho_goo_18 >> + bind_gPooP_stat_39<< + unbind_gPooP_stat_39>> + bind_gPooP_stat_40<< + unbind_gPooP_stat_40>> + unbind_s_goo_57>> + bind_gPooP_socs_76<< + unbind_gPooP_socs_76>> + bind_gPooP_socs_77<< + unbind_gPooP_socs_77>> + dephospho_goo_17<< + dephospho_goo_18<< ; //18 STAT3:gp130_P:LIF:LIFR = bind_gPll_stat_25>> + unbind_gPll_stat_25<< + phospho_sgll_19<< + dephospho_sgll_19>> ; //19 gp130:LIF:LIFR_P:STAT3 = bind_gllP_stat_26>> + unbind_gllP_stat_26<< + phospho_glls_20<< + dephospho_glls_20>> ; //20 STAT3:gp130_P:LIF:LIFR_P = bind_gPllP_stat_27>> + unbind_gPllP_stat_27<< + bind_sgPllP_stat_29<< + unbind_sgPllP_stat_29>> + phospho_sgll_19>> + dephospho_sgll_19<< ; //21 gp130_P:LIF:LIFR_P:STAT3 = bind_gPllP_stat_28>> + unbind_gPllP_stat_28<< + bind_gPllPs_stat_30<< + unbind_gPllPs_stat_30>> + phospho_glls_20>> + dephospho_glls_20<< ; //22 STAT3:gp130_P:LIF:LIFR_P:STAT3 = bind_sgPllP_stat_29>> + unbind_sgPllP_stat_29<< + bind_gPllPs_stat_30>> + unbind_gPllPs_stat_30<< + phospho_stat_sglls_43<< + phospho_stat_sglls_44<< + dephospho_stat_sglls_43>> + dephospho_stat_sglls_44>> ; //23 STAT3:gp130_P:OSM:LIFR = bind_gPol_stat_31>> + unbind_gPol_stat_31<< + phospho_sgol_21<< + dephospho_sgol_21>> ; //24 gp130:OSM:LIFR_P:STAT3 = bind_golP_stat_32>> + unbind_golP_stat_32<< + phospho_gols_22<< + dephospho_gols_22>> ; //25 STAT3:gp130_P:OSM:LIFR_P = bind_gPolP_stat_33>> + unbind_gPolP_stat_33<< + bind_sgPolP_stat_35<< + unbind_sgPolP_stat_35>> + phospho_sgol_21>> + dephospho_sgol_21<< ; //26 gp130_P:OSM:LIFR_P:STAT3 = bind_gPolP_stat_34>> + unbind_gPolP_stat_34<< + bind_gPolPs_stat_36<< + unbind_gPolPs_stat_36>> + phospho_gols_22>> + dephospho_gols_22<< ; //27 STAT3:gp130_P:OSM:LIFR_P:STAT3 = bind_sgPolP_stat_35>> + unbind_sgPolP_stat_35<< + bind_gPolPs_stat_36>> + unbind_gPolPs_stat_36<< + phospho_stat_sgols_47<< + phospho_stat_sgols_48<< + dephospho_stat_sgols_47>> + dephospho_stat_sgols_48>> ; //28 STAT3:gp130_P:OSM:OSMR = bind_gPoo_stat_37>> + unbind_gPoo_stat_37<< + phospho_sgoo_23<< + dephospho_sgoo_23>> ; //29 gp130:OSM:OSMR_P:STAT3 = bind_gooP_stat_38>> + unbind_gooP_stat_38<< + phospho_goos_24<< + dephospho_goos_24>> ; //30 STAT3:gp130_P:OSM:OSMR_P = bind_gPooP_stat_39>> + unbind_gPooP_stat_39<< + bind_sgPooP_stat_41<< + unbind_sgPooP_stat_41>> + phospho_sgoo_23>> + dephospho_sgoo_23<< ; //31 gp130_P:OSM:OSMR_P:STAT3 = bind_gPooP_stat_40>> + unbind_gPooP_stat_40<< + bind_gPooPs_stat_42<< + unbind_gPooPs_stat_42>> + phospho_goos_24>> + dephospho_goos_24<< ; //32 STAT3:gp130_P:OSM:OSMR_P:STAT3 = bind_sgPooP_stat_41>> + unbind_sgPooP_stat_41<< + bind_gPooPs_stat_42>> + unbind_gPooPs_stat_42<< + phospho_stat_sgoos_51<< + phospho_stat_sgoos_52<< + dephospho_stat_sgoos_51>> + dephospho_stat_sgoos_52>> ; //33 STAT3_P:gp130_P:LIF:LIFR_P:STAT3 = phospho_stat_sglls_43 >> + phospho_stat_sPglls_45 << + dephospho_stat_sglls_43<< + dephospho_stat_sPglls_45>> ; //34 STAT3:gp130_P:LIF:LIFR_P:STAT3_P = phospho_stat_sglls_44 >> + phospho_stat_sgllsP_46 << + dephospho_stat_sglls_44<< + dephospho_stat_sgllsP_46>> ; //35 STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P = phospho_stat_sPglls_45 >> + phospho_stat_sgllsP_46 >> + unbind_s_gll_55<< + dephospho_stat_sPglls_45<< + dephospho_stat_sgllsP_46<< ; //36 STAT3_P:gp130_P:OSM:LIFR_P:STAT3 = phospho_stat_sgols_47 >> + phospho_stat_sPgols_49 << + dephospho_stat_sgols_47<< + dephospho_stat_sPgols_49>> ; //37 STAT3:gp130_P:OSM:LIFR_P:STAT3_P = phospho_stat_sgols_48 >> + phospho_stat_sgolsP_50 << + dephospho_stat_sgols_48<< + dephospho_stat_sgolsP_50>> ; //38 STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P = phospho_stat_sPgols_49 >> + phospho_stat_sgolsP_50 >> + unbind_s_gol_56<< + dephospho_stat_sPgols_49<< + dephospho_stat_sgolsP_50<< ; //39 STAT3_P:gp130_P:OSM:OSMR_P:STAT3 = phospho_stat_sgoos_51 >> + phospho_stat_sPgoos_53 << + dephospho_stat_sgoos_51<< + dephospho_stat_sPgoos_53>> ; //40 STAT3:gp130_P:OSM:OSMR_P:STAT3_P = phospho_stat_sgoos_52 >> + phospho_stat_sgoosP_54 << + dephospho_stat_sgoos_52<< + dephospho_stat_sgoosP_54>> ; //41 STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P = phospho_stat_sPgoos_53 >> + phospho_stat_sgoosP_54 >> + unbind_s_goo_57<< + dephospho_stat_sPgoos_53<< + dephospho_stat_sgoosP_54<< ; //42 STAT3_c = bind_gPll_stat_25<< + unbind_gPll_stat_25>> + bind_gllP_stat_26<< + unbind_gllP_stat_26>> + bind_gPllP_stat_27<< + unbind_gPllP_stat_27>> + bind_gPllP_stat_28<< + unbind_gPllP_stat_28>> + bind_sgPllP_stat_29<< + unbind_sgPllP_stat_29>> + bind_gPllPs_stat_30<< + unbind_gPllPs_stat_30>> + bind_gPol_stat_31<< + unbind_gPol_stat_31>> + bind_golP_stat_32<< + unbind_golP_stat_32>> + bind_gPolP_stat_33<< + unbind_gPolP_stat_33>> + bind_gPolP_stat_34<< + unbind_gPolP_stat_34>> + bind_sgPolP_stat_35<< + unbind_sgPolP_stat_35>> + bind_gPolPs_stat_36<< + unbind_gPolPs_stat_36>> + bind_gPoo_stat_37<< + unbind_gPoo_stat_37>> + bind_gooP_stat_38<< + unbind_gooP_stat_38>> + bind_gPooP_stat_39<< + unbind_gPooP_stat_39>> + bind_gPooP_stat_40<< + unbind_gPooP_stat_40>> + bind_sgPooP_stat_41<< + unbind_sgPooP_stat_41>> + bind_gPooPs_stat_42<< + unbind_gPooPs_stat_42>> + reloc_stat_nc_60>> ; //43 STAT3_PD_c = unbind_s_gll_55>> + unbind_s_gol_56>> + unbind_s_goo_57>> + reloc_stat_cn_58<< ; //44 STAT3_PD_n = reloc_stat_cn_58>> + (synth_socs_61,1)(+) + dephospho_dedimer_stat_59<< + bind_pias_stat_80<< + unbind_pias_stat_80>> ; //45 STAT3_n = (dephospho_dedimer_stat_59,2)>> + reloc_stat_nc_60<< ; //46 SOCS3 = synth_socs_61>> + degr_socs_81<< + bind_gPll_socs_62<< + unbind_gPll_socs_62>> + bind_gllP_socs_63<< + unbind_gllP_socs_63>> + bind_gPllP_socs_64<< + unbind_gPllP_socs_64>> + bind_gPllP_socs_65<< + unbind_gPllP_socs_65>> + bind_sgPllP_socs_66<< + unbind_sgPllP_socs_66>> + bind_gPllPs_socs_67<< + unbind_gPllPs_socs_67>> + bind_gPol_socs_68<< + unbind_gPol_socs_68>> + bind_golP_socs_69<< + unbind_golP_socs_69>> + bind_gPolP_socs_70<< + unbind_gPolP_socs_70>> + bind_gPolP_socs_71<< + unbind_gPolP_socs_71>> + bind_sgPolP_socs_72<< + unbind_sgPolP_socs_72>> + bind_gPolPs_socs_73<< + unbind_gPolPs_socs_73>> + bind_gPoo_socs_74<< + unbind_gPoo_socs_74>> + bind_gooP_socs_75<< + unbind_gooP_socs_75>> + bind_gPooP_socs_76<< + unbind_gPooP_socs_76>> + bind_gPooP_socs_77<< + unbind_gPooP_socs_77>> + bind_sgPooP_socs_78<< + unbind_sgPooP_socs_78>> + bind_gPooPs_socs_79<< + unbind_gPooPs_socs_79>> ; SOCS3_dummy_source = synth_socs_61<< + degr_socs_81>> ; //47 SOCS3:gp130_P:LIF:LIFR = bind_gPll_socs_62>> + unbind_gPll_socs_62<< ; //48 gp130:LIF:LIFR_P:SOCS3 = bind_gllP_socs_63>> + unbind_gllP_socs_63<< ; //49 SOCS3:gp130_P:LIF:LIFR_P = bind_gPllP_socs_64>> + unbind_gPllP_socs_64<< + bind_sgPllP_socs_66<< + unbind_sgPllP_socs_66>> ; //50 gp130_P:LIF:LIFR_P:SOCS3 = bind_gPllP_socs_65>> + unbind_gPllP_socs_65<< + bind_gPllPs_socs_67<< + unbind_gPllPs_socs_67>> ; //51 SOCS3:gp130_P:LIF:LIFR_P:SOCS3 = bind_sgPllP_socs_66>> + unbind_sgPllP_socs_66<< + bind_gPllPs_socs_67>> + unbind_gPllPs_socs_67<< ; //52 SOCS3:gp130_P:OSM:LIFR = bind_gPol_socs_68>> + unbind_gPol_socs_68<< ; //53 gp130:OSM:LIFR_P:SOCS3 = bind_golP_socs_69>> + unbind_golP_socs_69<< ; //54 SOCS3:gp130_P:OSM:LIFR_P = bind_gPolP_socs_70>> + unbind_gPolP_socs_70<< + bind_sgPolP_socs_72<< + unbind_sgPolP_socs_72>> ; //55 gp130_P:OSM:LIFR_P:SOCS3 = bind_gPolP_socs_71>> + unbind_gPolP_socs_71<< + bind_gPolPs_socs_73<< + unbind_gPolPs_socs_73>> ; //56 SOCS3:gp130_P:OSM:LIFR_P:SOCS3 = bind_sgPolP_socs_72>> + unbind_sgPolP_socs_72<< + bind_gPolPs_socs_73>> + unbind_gPolPs_socs_73<< ; //57 SOCS3:gp130_P:OSM:OSMR = bind_gPoo_socs_74>> + unbind_gPoo_socs_74<< ; //58 gp130:OSM:OSMR_P:SOCS3 = bind_gooP_socs_75>> + unbind_gooP_socs_75<< ; //59 SOCS3:gp130_P:OSM:OSMR_P = bind_gPooP_socs_76>> + unbind_gPooP_socs_76<< + bind_sgPooP_socs_78<< + unbind_sgPooP_socs_78>> ; //60 gp130_P:OSM:OSMR_P:SOCS3 = bind_gPooP_socs_77>> + unbind_gPooP_socs_77<< + bind_gPooPs_socs_79<< + unbind_gPooPs_socs_79>> ; //61 SOCS3:gp130_P:OSM:OSMR_P:SOCS3 = bind_sgPooP_socs_78>> + unbind_sgPooP_socs_78<< + bind_gPooPs_socs_79>> + unbind_gPooPs_socs_79<< ; //62 PIAS3 = bind_pias_stat_80<< + unbind_pias_stat_80>> ; //63 PIAS3:STAT3_PD_n = bind_pias_stat_80>> + unbind_pias_stat_80<< ; LIF[LIF_init] <*> gp130 [gp130_init] <*> LIFR [LIFR_init] <*> OSM [OSM_init] <*> OSMR [OSMR_init] <*> gp130:LIF:LIFR [gp130:LIF:LIFR_init] <*> gp130:OSM:LIFR [gp130:OSM:LIFR_init] <*> gp130:OSM:OSMR [gp130:OSM:OSMR_init] <*> gp130_P:LIF:LIFR [gp130_P:LIF:LIFR_init] <*> gp130:LIF:LIFR_P [gp130:LIF:LIFR_P_init] <*> gp130_P:LIF:LIFR_P [gp130_P:LIF:LIFR_P_init] <*> gp130_P:OSM:LIFR [gp130_P:OSM:LIFR_init] <*> gp130:OSM:LIFR_P [gp130:OSM:LIFR_P_init] <*> gp130_P:OSM:LIFR_P [gp130_P:OSM:LIFR_P_init] <*> gp130_P:OSM:OSMR [gp130_P:OSM:OSMR_init] <*> gp130:OSM:OSMR_P [gp130:OSM:OSMR_P_init] <*> gp130_P:OSM:OSMR_P [gp130_P:OSM:OSMR_P_init] <*> STAT3:gp130_P:LIF:LIFR_P [STAT3:gp130_P:LIF:LIFR_P_init] <*> gp130_P:LIF:LIFR_P:STAT3 [gp130_P:LIF:LIFR_P:STAT3_init] <*> STAT3:gp130_P:LIF:LIFR_P:STAT3 [STAT3:gp130_P:LIF:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:LIFR_P [STAT3:gp130_P:OSM:LIFR_P_init] <*> gp130_P:OSM:LIFR_P:STAT3 [gp130_P:OSM:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:LIFR_P:STAT3 [STAT3:gp130_P:OSM:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:OSMR_P [STAT3:gp130_P:OSM:OSMR_P_init] <*> gp130_P:OSM:OSMR_P:STAT3 [gp130_P:OSM:OSMR_P:STAT3_init] <*> STAT3:gp130_P:OSM:OSMR_P:STAT3 [STAT3:gp130_P:OSM:OSMR_P:STAT3_init] <*> STAT3_P:gp130_P:LIF:LIFR_P:STAT3 [STAT3_P:gp130_P:LIF:LIFR_P:STAT3_init] <*> STAT3:gp130_P:LIF:LIFR_P:STAT3_P [STAT3:gp130_P:LIF:LIFR_P:STAT3_P_init] <*> STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P [STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P_init] <*> STAT3_P:gp130_P:OSM:LIFR_P:STAT3 [STAT3_P:gp130_P:OSM:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:LIFR_P:STAT3_P [STAT3:gp130_P:OSM:LIFR_P:STAT3_P_init] <*> STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P [STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P_init] <*> STAT3_P:gp130_P:OSM:OSMR_P:STAT3 [STAT3_P:gp130_P:OSM:OSMR_P:STAT3_init] <*> STAT3:gp130_P:OSM:OSMR_P:STAT3_P [STAT3:gp130_P:OSM:OSMR_P:STAT3_P_init] <*> STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P [STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P_init] <*> STAT3_c [STAT3_c_init] <*> STAT3_PD_c [STAT3_PD_c_init] <*> STAT3_PD_n [STAT3_PD_n_init] <*> STAT3_n [STAT3_n_init] <*> SOCS3 [SOCS3_init] <*> SOCS3_dummy_source [SOCS3_dummy_source_init] <*> SOCS3:gp130_P:LIF:LIFR [SOCS3:gp130_P:LIF:LIFR_init] <*> gp130:LIF:LIFR_P:SOCS3 [gp130:LIF:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:LIF:LIFR_P [SOCS3:gp130_P:LIF:LIFR_P_init] <*> gp130_P:LIF:LIFR_P:SOCS3 [gp130_P:LIF:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:LIF:LIFR_P:SOCS3 [SOCS3:gp130_P:LIF:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:LIFR [SOCS3:gp130_P:OSM:LIFR_init] <*> gp130:OSM:LIFR_P:SOCS3 [gp130:OSM:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:LIFR_P [SOCS3:gp130_P:OSM:LIFR_P_init] <*> gp130_P:OSM:LIFR_P:SOCS3 [gp130_P:OSM:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:LIFR_P:SOCS3 [SOCS3:gp130_P:OSM:LIFR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:OSMR [SOCS3:gp130_P:OSM:OSMR_init] <*> gp130:OSM:OSMR_P:SOCS3 [gp130:OSM:OSMR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:OSMR_P [SOCS3:gp130_P:OSM:OSMR_P_init] <*> gp130_P:OSM:OSMR_P:SOCS3 [gp130_P:OSM:OSMR_P:SOCS3_init] <*> SOCS3:gp130_P:OSM:OSMR_P:SOCS3 [SOCS3:gp130_P:OSM:OSMR_P:SOCS3_init] <*> PIAS3 [PIAS3_init] <*> PIAS3:STAT3_PD_n [PIAS3:STAT3_PD_n_init] <*> STAT3:gp130_P:LIF:LIFR [STAT3:gp130_P:LIF:LIFR_init] <*> gp130:LIF:LIFR_P:STAT3 [gp130:LIF:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:LIFR [STAT3:gp130_P:OSM:LIFR_init] <*> gp130:OSM:LIFR_P:STAT3 [gp130:OSM:LIFR_P:STAT3_init] <*> STAT3:gp130_P:OSM:OSMR [STAT3:gp130_P:OSM:OSMR_init] <*> gp130:OSM:OSMR_P:STAT3 [gp130:OSM:OSMR_P:STAT3_init]