% BioPEPA model of gp130/STAT pathway %biopepa.independent.replications: 1 %biopepa.show.all.replications: false %biopepa.simulation.stoptime: 500 %stochkit.opt.progress.interval: 100 %ligands_receptors binding/unbinding bind_gl_l_1 = [k1 * gp130 * LIF * LIFR ]; bind_ll_g_2 = [k2 * LIFR * LIF * gp130 ]; bind_go_l_3 = [k3 * gp130 * OSM * LIFR ]; bind_lo_g_4 = [k4 * LIFR * OSM * gp130 ]; bind_oo_g_5 = [k5 * OSMR * OSM * gp130 ]; bind_go_o_6 = [k6 * gp130 * OSM * OSMR ]; %receptors phosphorylation phospho_gll_7 = [k7 * gp130:LIF:LIFR ]; phospho_gll_8 = [k8 * gp130:LIF:LIFR ]; phospho_gll_9 = [k9 * gp130_P:LIF:LIFR ]; phospho_gll_10 = [k10 * gp130:LIF:LIFR_P ]; phospho_gol_11 = [k11 * gp130:OSM:LIFR ]; phospho_gol_12 = [k12 * gp130:OSM:LIFR ]; phospho_gol_13 = [k13 * gp130_P:OSM:LIFR ]; phospho_gol_14 = [k14 * gp130:OSM:LIFR_P ]; phospho_goo_15 = [k15 * gp130:OSM:OSMR ]; phospho_goo_16 = [k16 * gp130:OSM:OSMR ]; phospho_goo_17 = [k17 * gp130_P:OSM:OSMR ]; phospho_goo_18 = [k18 * gp130:OSM:OSMR_P ]; phospho_sgll_19 = [k19 * STAT3:gp130_P:LIF:LIFR ]; phospho_glls_20 = [k20 * gp130:LIF:LIFR_P:STAT3 ]; phospho_sgol_21 = [k21 * STAT3:gp130_P:OSM:LIFR ]; phospho_gols_22 = [k22 * gp130:OSM:LIFR_P:STAT3 ]; phospho_sgoo_23 = [k23 * STAT3:gp130_P:OSM:OSMR ]; phospho_goos_24 = [k24 * gp130:OSM:OSMR_P:STAT3 ]; %receptors_STAT3 binding/unbinding bind_gPll_stat_25 = [k25 * gp130_P:LIF:LIFR * STAT3_c ]; unbind_gPll_stat_25 = [km25 * STAT3:gp130_P:LIF:LIFR ]; bind_gllP_stat_26 = [k26 * gp130:LIF:LIFR_P * STAT3_c ]; unbind_gllP_stat_26 = [km26 * gp130:LIF:LIFR_P:STAT3 ]; bind_gPllP_stat_27 = [k27 * gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_gPllP_stat_27 = [km27 * STAT3:gp130_P:LIF:LIFR_P ]; bind_gPllP_stat_28 = [k28 * gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_gPllP_stat_28 = [km28 * gp130_P:LIF:LIFR_P:STAT3 ]; bind_sgPllP_stat_29 = [k29 * STAT3:gp130_P:LIF:LIFR_P * STAT3_c ]; unbind_sgPllP_stat_29 = [km29 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; bind_gPllPs_stat_30 = [k30 * gp130_P:LIF:LIFR_P:STAT3 * STAT3_c ]; unbind_gPllPs_stat_30 = [km30 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; bind_gPol_stat_31 = [k31 * gp130_P:OSM:LIFR * STAT3_c ]; unbind_gPol_stat_31 = [km31 * STAT3:gp130_P:OSM:LIFR ]; bind_golP_stat_32 = [k32 * gp130:OSM:LIFR_P * STAT3_c ]; unbind_golP_stat_32 = [km32 * gp130:OSM:LIFR_P:STAT3 ]; bind_gPolP_stat_33 = [k33 * gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_gPolP_stat_33 = [km33 * STAT3:gp130_P:OSM:LIFR_P ]; bind_gPolP_stat_34 = [k34 * gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_gPolP_stat_34 = [km34 * gp130_P:OSM:LIFR_P:STAT3 ]; bind_sgPolP_stat_35 = [k35 * STAT3:gp130_P:OSM:LIFR_P * STAT3_c ]; unbind_sgPolP_stat_35 = [km35 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; bind_gPolPs_stat_36 = [k36 * gp130_P:OSM:LIFR_P:STAT3 * STAT3_c ]; unbind_gPolPs_stat_36 = [km36 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; bind_gPoo_stat_37 = [k37 * gp130_P:OSM:OSMR * STAT3_c ]; unbind_gPoo_stat_37 = [km37 * STAT3:gp130_P:OSM:OSMR ]; bind_gooP_stat_38 = [k38 * gp130:OSM:OSMR_P * STAT3_c ]; unbind_gooP_stat_38 = [km38 * gp130:OSM:OSMR_P:STAT3 ]; bind_gPooP_stat_39 = [k39 * gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_gPooP_stat_39 = [km39 * STAT3:gp130_P:OSM:OSMR_P ]; bind_gPooP_stat_40 = [k40 * gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_gPooP_stat_40 = [km40 * gp130_P:OSM:OSMR_P:STAT3 ]; bind_sgPooP_stat_41 = [k41 * STAT3:gp130_P:OSM:OSMR_P * STAT3_c ]; unbind_sgPooP_stat_41 = [km41 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; bind_gPooPs_stat_42 = [k42 * gp130_P:OSM:OSMR_P:STAT3 * STAT3_c ]; unbind_gPooPs_stat_42 = [km42 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; %STAT3 phosphorylation phospho_stat_sglls_43 = [k43 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; phospho_stat_sglls_44 = [k44 * STAT3:gp130_P:LIF:LIFR_P:STAT3 ]; phospho_stat_sPglls_45 = [k45 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3 ]; phospho_stat_sgllsP_46 = [k46 * STAT3:gp130_P:LIF:LIFR_P:STAT3_P ]; phospho_stat_sgols_47 = [k47 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; phospho_stat_sgols_48 = [k48 * STAT3:gp130_P:OSM:LIFR_P:STAT3 ]; phospho_stat_sPgols_49 = [k49 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3 ]; phospho_stat_sgolsP_50 = [k50 * STAT3:gp130_P:OSM:LIFR_P:STAT3_P ]; phospho_stat_sgoos_51 = [k51 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; phospho_stat_sgoos_52 = [k52 * STAT3:gp130_P:OSM:OSMR_P:STAT3 ]; phospho_stat_sPgoos_53 = [k53 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3 ]; phospho_stat_sgoosP_54 = [k54 * STAT3:gp130_P:OSM:OSMR_P:STAT3_P ]; %STAT3 unbinding & homodimerization unbind_s_gll_55 = [k55 * STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P ]; unbind_s_gol_56 = [k56 * STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P ]; unbind_s_goo_57 = [k57 * STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P ]; %STAT3PD relocation cytoplasm -> nucleus reloc_stat_cn_58 = [(0.693 / k58) * STAT3_PD_c ]; %STAT3PDN dephosphorylation & dedimerization dephospho_dedimer_stat_59 = [k59 * STAT3_PD_n ]; %STAT3PDN relocation nucleus -> cytoplasm reloc_stat_nc_60 = [(0.693 / k60) * STAT3_n ]; %SOCS3 synthesis by STAT3_PD_n synth_socs_61 = [k61 * STAT3_PD_n ]; %receptors_SOCS3 binding/unbinding bind_gPll_socs_62 = [k62 * gp130_P:LIF:LIFR * SOCS3 ]; unbind_gPll_socs_62 = [km62 * SOCS3:gp130_P:LIF:LIFR ]; bind_gllP_socs_63 = [k63 * gp130:LIF:LIFR_P * SOCS3 ]; unbind_gllP_socs_63 = [km63 * gp130:LIF:LIFR_P:SOCS3 ]; bind_gPllP_socs_64 = [k64 * gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_gPllP_socs_64 = [km64 * SOCS3:gp130_P:LIF:LIFR_P ]; bind_gPllP_socs_65 = [k65 * gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_gPllP_socs_65 = [km65 * gp130_P:LIF:LIFR_P:SOCS3 ]; bind_sgPllP_socs_66 = [k66 * SOCS3:gp130_P:LIF:LIFR_P * SOCS3 ]; unbind_sgPllP_socs_66 = [km66 * SOCS3:gp130_P:LIF:LIFR_P:SOCS3 ]; bind_gPllPs_socs_67 = [k67 * gp130_P:LIF:LIFR_P:SOCS3 * SOCS3 ]; unbind_gPllPs_socs_67 = [km67 * SOCS3:gp130_P:LIF:LIFR_P:SOCS3 ]; bind_gPol_socs_68 = [k68 * gp130_P:OSM:LIFR * SOCS3 ]; unbind_gPol_socs_68 = [km68 * SOCS3:gp130_P:OSM:LIFR ]; bind_golP_socs_69 = [k69 * gp130:OSM:LIFR_P * SOCS3 ]; unbind_golP_socs_69 = [km69 * gp130:OSM:LIFR_P:SOCS3 ]; bind_gPolP_socs_70 = [k70 * gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_gPolP_socs_70 = [km70 * SOCS3:gp130_P:OSM:LIFR_P ]; bind_gPolP_socs_71 = [k71 * gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_gPolP_socs_71 = [km71 * gp130_P:OSM:LIFR_P:SOCS3 ]; bind_sgPolP_socs_72 = [k72 * SOCS3:gp130_P:OSM:LIFR_P * SOCS3 ]; unbind_sgPolP_socs_72 = [km72 * SOCS3:gp130_P:OSM:LIFR_P:SOCS3 ]; bind_gPolPs_socs_73 = [k73 * gp130_P:OSM:LIFR_P:SOCS3 * SOCS3 ]; unbind_gPolPs_socs_73 = [km73 * SOCS3:gp130_P:OSM:LIFR_P:SOCS3 ]; bind_gPoo_socs_74 = [k74 * gp130_P:OSM:OSMR * SOCS3 ]; unbind_gPoo_socs_74 = [km74 * SOCS3:gp130_P:OSM:OSMR ]; bind_gooP_socs_75 = [k75 * gp130:OSM:OSMR_P * SOCS3 ]; unbind_gooP_socs_75 = [km75 * gp130:OSM:OSMR_P:SOCS3 ]; bind_gPooP_socs_76 = [k76 * gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_gPooP_socs_76 = [km76 * SOCS3:gp130_P:OSM:OSMR_P ]; bind_gPooP_socs_77 = [k77 * gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_gPooP_socs_77 = [km77 * gp130_P:OSM:OSMR_P:SOCS3 ]; bind_sgPooP_socs_78 = [k78 * SOCS3:gp130_P:OSM:OSMR_P * SOCS3 ]; unbind_sgPooP_socs_78 = [km78 * SOCS3:gp130_P:OSM:OSMR_P:SOCS3 ]; bind_gPooPs_socs_79 = [k79 * gp130_P:OSM:OSMR_P:SOCS3 * SOCS3 ]; unbind_gPooPs_socs_79 = [km79 * SOCS3:gp130_P:OSM:OSMR_P:SOCS3 ]; %PIAS3_STAT3PD_n bind_pias_stat_80 = [k80 * PIAS3 * STAT3_PD_n ]; unbind_pias_stat_80 = [km80 * PIAS3:STAT3_PD_n ]; degr_socs_81 = [k81 * SOCS3 ]; %1 LIF = bind_gl_l_1<< + bind_ll_g_2<< ; %2 gp130 = bind_gl_l_1<< + bind_go_l_3<< + bind_go_o_6<< + bind_ll_g_2<< + bind_lo_g_4<< + bind_oo_g_5<< ; %3 LIFR = bind_ll_g_2<< + bind_lo_g_4<< + bind_gl_l_1<< + bind_go_l_3<< ; %4 OSM = bind_go_l_3<< + bind_lo_g_4<< + bind_oo_g_5<< + bind_go_o_6<< ; %5 OSMR = bind_oo_g_5<< + bind_go_o_6<< ; %6 gp130:LIF:LIFR = bind_gl_l_1>> + bind_ll_g_2>> + phospho_gll_7<< + phospho_gll_8<< ; %7 gp130:OSM:LIFR = bind_go_l_3>> + bind_lo_g_4>> + phospho_gol_11<< + phospho_gol_12<< ; %8 gp130:OSM:OSMR = bind_oo_g_5>> + bind_go_o_6>> + phospho_goo_15<< + phospho_goo_16<< ; %9 gp130_P:LIF:LIFR = phospho_gll_7>> + phospho_gll_9<< + bind_gPll_stat_25<< + unbind_gPll_stat_25>> + bind_gPll_socs_62<< + unbind_gPll_socs_62>> ; %10 gp130:LIF:LIFR_P = phospho_gll_8>> + phospho_gll_10<< + bind_gllP_stat_26<< + unbind_gllP_stat_26>> + bind_gllP_socs_63<< + unbind_gllP_socs_63>> ; %11 gp130_P:LIF:LIFR_P = phospho_gll_9>> + phospho_gll_10>> + bind_gPllP_stat_27<< + unbind_gPllP_stat_27>> + bind_gPllP_stat_28<< + unbind_gPllP_stat_28>> + unbind_s_gll_55>> + bind_gPllP_socs_64<< + unbind_gPllP_socs_64>> + bind_gPllP_socs_65<< + unbind_gPllP_socs_65>> ; %12 gp130_P:OSM:LIFR = phospho_gol_11>> + phospho_gol_13<< + bind_gPol_stat_31<< + unbind_gPol_stat_31>> + bind_gPol_socs_68<< + unbind_gPol_socs_68>> ; %13 gp130:OSM:LIFR_P = phospho_gol_12>> + phospho_gol_14<< + bind_golP_stat_32<< + unbind_golP_stat_32>> + bind_golP_socs_69<< + unbind_golP_socs_69>> ; %14 gp130_P:OSM:LIFR_P = phospho_gol_13>> + phospho_gol_14>> + bind_gPolP_stat_33<< + unbind_gPolP_stat_33>> + bind_gPolP_stat_34<< + unbind_gPolP_stat_34>> + unbind_s_gol_56>> + bind_gPolP_socs_70<< + unbind_gPolP_socs_70>> + bind_gPolP_socs_71<< + unbind_gPolP_socs_71>> ; %15 gp130_P:OSM:OSMR = phospho_goo_15>> + phospho_goo_17<< + bind_gPoo_stat_37<< + unbind_gPoo_stat_37>> + bind_gPoo_socs_74<< + unbind_gPoo_socs_74>> ; %16 gp130:OSM:OSMR_P = phospho_goo_16>> + phospho_goo_18<< + bind_gooP_stat_38<< + unbind_gooP_stat_38>> + bind_gooP_socs_75<< + unbind_gooP_socs_75>> ; %17 gp130_P:OSM:OSMR_P = phospho_goo_17>> + phospho_goo_18>> + bind_gPooP_stat_39<< + unbind_gPooP_stat_39>> + bind_gPooP_stat_40<< + unbind_gPooP_stat_40>> + unbind_s_goo_57>> + bind_gPooP_socs_76<< + unbind_gPooP_socs_76>> + bind_gPooP_socs_77<< + unbind_gPooP_socs_77>> ; %18 STAT3:gp130_P:LIF:LIFR = bind_gPll_stat_25>> + unbind_gPll_stat_25<< + phospho_sgll_19<< ; %19 gp130:LIF:LIFR_P:STAT3 = bind_gllP_stat_26>> + unbind_gllP_stat_26<< + phospho_glls_20<< ; %20 STAT3:gp130_P:LIF:LIFR_P = bind_gPllP_stat_27>> + unbind_gPllP_stat_27<< + bind_sgPllP_stat_29<< + unbind_sgPllP_stat_29>> + phospho_sgll_19>> ; %21 gp130_P:LIF:LIFR_P:STAT3 = bind_gPllP_stat_28>> + unbind_gPllP_stat_28<< + bind_gPllPs_stat_30<< + unbind_gPllPs_stat_30>> + phospho_glls_20>> ; %22 STAT3:gp130_P:LIF:LIFR_P:STAT3 = bind_sgPllP_stat_29>> + unbind_sgPllP_stat_29<< + bind_gPllPs_stat_30>> + unbind_gPllPs_stat_30<< + phospho_stat_sglls_43<< + phospho_stat_sglls_44<< ; %23 STAT3:gp130_P:OSM:LIFR = bind_gPol_stat_31>> + unbind_gPol_stat_31<< + phospho_sgol_21<< ; %24 gp130:OSM:LIFR_P:STAT3 = bind_golP_stat_32>> + unbind_golP_stat_32<< + phospho_gols_22<< ; %25 STAT3:gp130_P:OSM:LIFR_P = bind_gPolP_stat_33>> + unbind_gPolP_stat_33<< + bind_sgPolP_stat_35<< + unbind_sgPolP_stat_35>> + phospho_sgol_21>> ; %26 gp130_P:OSM:LIFR_P:STAT3 = bind_gPolP_stat_34>> + unbind_gPolP_stat_34<< + bind_gPolPs_stat_36<< + unbind_gPolPs_stat_36>> + phospho_gols_22>> ; %27 STAT3:gp130_P:OSM:LIFR_P:STAT3 = bind_sgPolP_stat_35>> + unbind_sgPolP_stat_35<< + bind_gPolPs_stat_36>> + unbind_gPolPs_stat_36<< + phospho_stat_sgols_47<< + phospho_stat_sgols_48<< ; %28 STAT3:gp130_P:OSM:OSMR = bind_gPoo_stat_37>> + unbind_gPoo_stat_37<< + phospho_sgoo_23<< ; %29 gp130:OSM:OSMR_P:STAT3 = bind_gooP_stat_38>> + unbind_gooP_stat_38<< + phospho_goos_24<< ; %30 STAT3:gp130_P:OSM:OSMR_P = bind_gPooP_stat_39>> + unbind_gPooP_stat_39<< + bind_sgPooP_stat_41<< + unbind_sgPooP_stat_41>> + phospho_sgoo_23>> ; %31 gp130_P:OSM:OSMR_P:STAT3 = bind_gPooP_stat_40>> + unbind_gPooP_stat_40<< + bind_gPooPs_stat_42<< + unbind_gPooPs_stat_42>> + phospho_goos_24>> ; %32 STAT3:gp130_P:OSM:OSMR_P:STAT3 = bind_sgPooP_stat_41>> + unbind_sgPooP_stat_41<< + bind_gPooPs_stat_42>> + unbind_gPooPs_stat_42<< + phospho_stat_sgoos_51<< + phospho_stat_sgoos_52<< ; %33 STAT3_P:gp130_P:LIF:LIFR_P:STAT3 = phospho_stat_sglls_43>> + phospho_stat_sPglls_45<< ; %34 STAT3:gp130_P:LIF:LIFR_P:STAT3_P = phospho_stat_sglls_44>> + phospho_stat_sgllsP_46<< ; %35 STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P = phospho_stat_sPglls_45>> + phospho_stat_sgllsP_46>> + unbind_s_gll_55<< ; %36 STAT3_P:gp130_P:OSM:LIFR_P:STAT3 = phospho_stat_sgols_47>> + phospho_stat_sPgols_49<< ; %37 STAT3:gp130_P:OSM:LIFR_P:STAT3_P = phospho_stat_sgols_48>> + phospho_stat_sgolsP_50<< ; %38 STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P = phospho_stat_sPgols_49>> + phospho_stat_sgolsP_50>> + unbind_s_gol_56<< ; %39 STAT3_P:gp130_P:OSM:OSMR_P:STAT3 = phospho_stat_sgoos_51>> + phospho_stat_sPgoos_53<< ; %40 STAT3:gp130_P:OSM:OSMR_P:STAT3_P = phospho_stat_sgoos_52>> + phospho_stat_sgoosP_54<< ; %41 STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P = phospho_stat_sPgoos_53>> + phospho_stat_sgoosP_54>> + unbind_s_goo_57<< ; %42 STAT3_c = bind_gPll_stat_25<< + unbind_gPll_stat_25>> + bind_gllP_stat_26<< + unbind_gllP_stat_26>> + bind_gPllP_stat_27<< + unbind_gPllP_stat_27>> + bind_gPllP_stat_28<< + unbind_gPllP_stat_28>> + bind_sgPllP_stat_29<< + unbind_sgPllP_stat_29>> + bind_gPllPs_stat_30<< + unbind_gPllPs_stat_30>> + bind_gPol_stat_31<< + unbind_gPol_stat_31>> + bind_golP_stat_32<< + unbind_golP_stat_32>> + bind_gPolP_stat_33<< + unbind_gPolP_stat_33>> + bind_gPolP_stat_34<< + unbind_gPolP_stat_34>> + bind_sgPolP_stat_35<< + unbind_sgPolP_stat_35>> + bind_gPolPs_stat_36<< + unbind_gPolPs_stat_36>> + bind_gPoo_stat_37<< + unbind_gPoo_stat_37>> + bind_gooP_stat_38<< + unbind_gooP_stat_38>> + bind_gPooP_stat_39<< + unbind_gPooP_stat_39>> + bind_gPooP_stat_40<< + unbind_gPooP_stat_40>> + bind_sgPooP_stat_41<< + unbind_sgPooP_stat_41>> + bind_gPooPs_stat_42<< + unbind_gPooPs_stat_42>> + reloc_stat_nc_60>> ; %43 STAT3_PD_c = unbind_s_gll_55>> + unbind_s_gol_56>> + unbind_s_goo_57>> + reloc_stat_cn_58<< ; %44 STAT3_PD_n = reloc_stat_cn_58>> + (synth_socs_61,1)(+) + dephospho_dedimer_stat_59<< + bind_pias_stat_80<< + unbind_pias_stat_80>> ; %45 STAT3_n = (dephospho_dedimer_stat_59,2)>> + reloc_stat_nc_60<< ; %46 SOCS3 = synth_socs_61>> + degr_socs_81<< + bind_gPll_socs_62<< + unbind_gPll_socs_62>> + bind_gllP_socs_63<< + unbind_gllP_socs_63>> + bind_gPllP_socs_64<< + unbind_gPllP_socs_64>> + bind_gPllP_socs_65<< + unbind_gPllP_socs_65>> + bind_sgPllP_socs_66<< + unbind_sgPllP_socs_66>> + bind_gPllPs_socs_67<< + unbind_gPllPs_socs_67>> + bind_gPol_socs_68<< + unbind_gPol_socs_68>> + bind_golP_socs_69<< + unbind_golP_socs_69>> + bind_gPolP_socs_70<< + unbind_gPolP_socs_70>> + bind_gPolP_socs_71<< + unbind_gPolP_socs_71>> + bind_sgPolP_socs_72<< + unbind_sgPolP_socs_72>> + bind_gPolPs_socs_73<< + unbind_gPolPs_socs_73>> + bind_gPoo_socs_74<< + unbind_gPoo_socs_74>> + bind_gooP_socs_75<< + unbind_gooP_socs_75>> + bind_gPooP_socs_76<< + unbind_gPooP_socs_76>> + bind_gPooP_socs_77<< + unbind_gPooP_socs_77>> + bind_sgPooP_socs_78<< + unbind_sgPooP_socs_78>> + bind_gPooPs_socs_79<< + unbind_gPooPs_socs_79>> ; %47 SOCS3:gp130_P:LIF:LIFR = bind_gPll_socs_62>> + unbind_gPll_socs_62<< ; %48 gp130:LIF:LIFR_P:SOCS3 = bind_gllP_socs_63>> + unbind_gllP_socs_63<< ; %49 SOCS3:gp130_P:LIF:LIFR_P = bind_gPllP_socs_64>> + unbind_gPllP_socs_64<< + bind_sgPllP_socs_66<< + unbind_sgPllP_socs_66>> ; %50 gp130_P:LIF:LIFR_P:SOCS3 = bind_gPllP_socs_65>> + unbind_gPllP_socs_65<< + bind_gPllPs_socs_67<< + unbind_gPllPs_socs_67>> ; %51 SOCS3:gp130_P:LIF:LIFR_P:SOCS3 = bind_sgPllP_socs_66>> + unbind_sgPllP_socs_66<< + bind_gPllPs_socs_67>> + unbind_gPllPs_socs_67<< ; %52 SOCS3:gp130_P:OSM:LIFR = bind_gPol_socs_68>> + unbind_gPol_socs_68<< ; %53 gp130:OSM:LIFR_P:SOCS3 = bind_golP_socs_69>> + unbind_golP_socs_69<< ; %54 SOCS3:gp130_P:OSM:LIFR_P = bind_gPolP_socs_70>> + unbind_gPolP_socs_70<< + bind_sgPolP_socs_72<< + unbind_sgPolP_socs_72>> ; %55 gp130_P:OSM:LIFR_P:SOCS3 = bind_gPolP_socs_71>> + unbind_gPolP_socs_71<< + bind_gPolPs_socs_73<< + unbind_gPolPs_socs_73>> ; %56 SOCS3:gp130_P:OSM:LIFR_P:SOCS3 = bind_sgPolP_socs_72>> + unbind_sgPolP_socs_72<< + bind_gPolPs_socs_73>> + unbind_gPolPs_socs_73<< ; %57 SOCS3:gp130_P:OSM:OSMR = bind_gPoo_socs_74>> + unbind_gPoo_socs_74<< ; %58 gp130:OSM:OSMR_P:SOCS3 = bind_gooP_socs_75>> + unbind_gooP_socs_75<< ; %59 SOCS3:gp130_P:OSM:OSMR_P = bind_gPooP_socs_76>> + unbind_gPooP_socs_76<< + bind_sgPooP_socs_78<< + unbind_sgPooP_socs_78>> ; %60 gp130_P:OSM:OSMR_P:SOCS3 = bind_gPooP_socs_77>> + unbind_gPooP_socs_77<< + bind_gPooPs_socs_79<< + unbind_gPooPs_socs_79>> ; %61 SOCS3:gp130_P:OSM:OSMR_P:SOCS3 = bind_sgPooP_socs_78>> + unbind_sgPooP_socs_78<< + bind_gPooPs_socs_79>> + unbind_gPooPs_socs_79<< ; %62 PIAS3 = bind_pias_stat_80<< + unbind_pias_stat_80>> ; %63 PIAS3:STAT3_PD_n = bind_pias_stat_80>> + unbind_pias_stat_80<< ; res = (degr_socs_81,1)(.) ; LIF <> gp130 <> LIFR <> OSM <> OSMR <> gp130:LIF:LIFR <> gp130:OSM:LIFR <> gp130:OSM:OSMR <> gp130_P:LIF:LIFR <> gp130:LIF:LIFR_P <> gp130_P:LIF:LIFR_P <> gp130_P:OSM:LIFR <> gp130:OSM:LIFR_P <> gp130_P:OSM:LIFR_P <> gp130_P:OSM:OSMR <> gp130:OSM:OSMR_P <> gp130_P:OSM:OSMR_P <> STAT3:gp130_P:LIF:LIFR_P <> gp130_P:LIF:LIFR_P:STAT3 <> STAT3:gp130_P:LIF:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:LIFR_P <> gp130_P:OSM:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:OSMR_P <> gp130_P:OSM:OSMR_P:STAT3 <> STAT3:gp130_P:OSM:OSMR_P:STAT3 <> STAT3_P:gp130_P:LIF:LIFR_P:STAT3 <> STAT3:gp130_P:LIF:LIFR_P:STAT3_P <> STAT3_P:gp130_P:LIF:LIFR_P:STAT3_P <> STAT3_P:gp130_P:OSM:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:LIFR_P:STAT3_P <> STAT3_P:gp130_P:OSM:LIFR_P:STAT3_P <> STAT3_P:gp130_P:OSM:OSMR_P:STAT3 <> STAT3:gp130_P:OSM:OSMR_P:STAT3_P <> STAT3_P:gp130_P:OSM:OSMR_P:STAT3_P <> STAT3_c <> STAT3_PD_c <> STAT3_PD_n <> STAT3_n <> SOCS3 <> SOCS3:gp130_P:LIF:LIFR <> gp130:LIF:LIFR_P:SOCS3 <> SOCS3:gp130_P:LIF:LIFR_P <> gp130_P:LIF:LIFR_P:SOCS3 <> SOCS3:gp130_P:LIF:LIFR_P:SOCS3 <> SOCS3:gp130_P:OSM:LIFR <> gp130:OSM:LIFR_P:SOCS3 <> SOCS3:gp130_P:OSM:LIFR_P <> gp130_P:OSM:LIFR_P:SOCS3 <> SOCS3:gp130_P:OSM:LIFR_P:SOCS3 <> SOCS3:gp130_P:OSM:OSMR <> gp130:OSM:OSMR_P:SOCS3 <> SOCS3:gp130_P:OSM:OSMR_P <> gp130_P:OSM:OSMR_P:SOCS3 <> SOCS3:gp130_P:OSM:OSMR_P:SOCS3 <> PIAS3 <> PIAS3:STAT3_PD_n <> STAT3:gp130_P:LIF:LIFR <> gp130:LIF:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:LIFR <> gp130:OSM:LIFR_P:STAT3 <> STAT3:gp130_P:OSM:OSMR <> gp130:OSM:OSMR_P:STAT3 <> res