Modelling trafficking of proteins within the mammalian cell using Bio-PEPA [extended abstract and poster]

V. Galpin

In Proceedings of the Tenth Conference on Computational Methods in Systems Biology (CMSB 2012), LNCS 7605, 374-377, Springer, 2012.


Bio-PEPA, a process algebra developed from PEPA is used to model a process occurring in mammalian cells whereby the Src oncoprotein is trafficked between different parts of the cell. Src is associated with cell movement and adhesion between cells which is linked to tumour formation. A useful model of the protein's behaviour can provide predictions for new experimental hypotheses which may improve our understanding, and in time, lead to new therapies for cancer. The aim is to assess the suitability of Bio-PEPA for more detailed modelling of Src trafficking than that of a previous simpler Bio-PEPA model. 


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