Modelling protein trafficking: progress and challenges (Invited talk)

V.C. Galpin

"Biology + Computing = ??" - A Joint SICSA CSE:SEABIS and ModAbs Meeting, University of Stirling, May 2012


Experimental research has shown that the oncoprotein Src is trafficked in endosomes between different parts of the cell. What techniques can be applied to develop a useful model that will provide hypotheses for further experimentation? What are the challenges involved when there is a lack of quantitative experimental data? This presentation describes how process algebra approaches have been applied to this difficult problem which involves dynamic behaviour, spatial aspects, and populations of independent entities. 

Slides - PDF