Biomolecular control group

Systems & Synthetic Biology at the University of Edinburgh

Our two locations: the Informatics Forum and the CH Waddington Building in Edinburgh.

what we do

Our team develops computational methods to study molecular processes in living cells. We use mathematics to understand natural networks and to design novel systems for biotechnology and biomedicine. We employ a wide range of methods, such as machine learning, control theory, stochastic analysis and network theory. Large parts of our work are in collaboration with Systems and Synthetic Biology labs in the UK and abroad.

who we are

The group lead is Diego Oyarzún and includes research students and postdocs. Together we gather expertise in many disciplines like machine learning, mathematics, biochemistry and bioinformatics.

where we work

We are very lucky to be located at the School of Informatics and the School of Biological Sciences of the University of Edinburgh, in one of the most vibrant European capitals. We are members of the Edinburgh Centre for Engineering Biology.

recent papers


Apr 18, 2024 Michael’s paper on protein structure and in vivo function is out in preprint, congrats for this very insightful work!
Apr 12, 2024 Diego will be speaking at the workshop AI Methods/Models for BioCatalysis and Synthetic Biology, University of Montpellier, France.
Apr 9, 2024 Charlotte’s paper on dynamic host-pathway interactions is out in preprint, congrats!
Apr 5, 2024 A warm welcome to Jeremy Boyle, who has joined the lab as PhD student in collaboration with the Regan and Orosa labs.
Mar 15, 2024 Diego will be speaking at the 5th Next Generation Synthetic Biology in Ghent, Belgium.
Mar 6, 2024 Ramin’s paper on graph neural networks for gene essentiality prediction has been published in npj Systems Biology and Applications. Many congrats!
Feb 28, 2024 Ricardo’s paper on active learning for chemical production has been published in Computational and Structural Biotechnology Journal. Many congrats!
Feb 23, 2024 Diego has been appointed Director of the UKRI Centre for Doctoral Training in Biomedical AI.
Feb 7, 2024 Yuxin’s paper on generalization performance of sequence-to-expression models is out in preprint, congrats!
Jan 15, 2024 Diego gave a talk at the Congreso Futuro 2024, sponsored by the Senate of Chile. You can check the talk here (in Spanish).